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Modern fungicides and mechanism of their action
Zaleš, František ; Gabriel, Jiří (advisor) ; Ptáček, Petr (referee)
Fungicides are compounds, which are able to kill a fungi (they are therefore fungicidal), or they are able to slow or stop growth of a fungi (they are therefore fungistatic). Some fungicides also have insecticidal properties and can offer dual protection. This bachelor thesis is mainly dealing with fungicides, which are used to protect wood and wooden constructions from wood decaying fungi. Part of this bachelor thesis is a brief overview of wood decaying fungi and also an insight into the history of fungicides, but the main goal of this thesis is to offer a survey of currently used fungicides for wood protection against wood decaying fungi and also describe the mechanism of their action. Keywords: fungi, fungicides, buildings, general threat, wood decay, mode of action
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Modern fungicides and mechanism of their action
Zaleš, František ; Gabriel, Jiří (advisor) ; Ptáček, Petr (referee)
Fungicides are compounds, which are able to kill a fungi (they are therefore fungicidal), or they are able to slow or stop growth of a fungi (they are therefore fungistatic). Some fungicides also have insecticidal properties and can offer dual protection. This bachelor thesis is mainly dealing with fungicides, which are used to protect wood and wooden constructions from wood decaying fungi. Part of this bachelor thesis is a brief overview of wood decaying fungi and also an insight into the history of fungicides, but the main goal of this thesis is to offer a survey of currently used fungicides for wood protection against wood decaying fungi and also describe the mechanism of their action. Keywords: fungi, fungicides, buildings, general threat, wood decay, mode of action
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Mechanisms and mode of action of essential oils on fungi
Ježková, Tereza ; Koukol, Ondřej (advisor) ; Čmoková, Adéla (referee)
Essential oils are volatile compounds from plants with a wide range of effects. Many of them exhibit antifungal activity. As the resistance of pathogenic fungi to antimycotics is increasing, finding new antifungal agents for the treatment of fungal infections is highly desirable. In order to use essential oils for the production of new drugs, it is necessary to know the exact mechanism of their action. Although it is known a lot about the effects of essential oils on fungi, the particular target in a cell is not always described. In this thesis I summarize the present knowledge about the mechanisms of actions on fungi. I gradually deal with effects of essential oils on cell wall, plasma membrane, mitochondrion, nucleus, quorum sensing, virulence factors, mycotoxin production and fungal development. Generally essential oils do not act on one structure but affect multiple structures and processes at the same time. In the last chapter I mention possible directions for further research of these substances. Key words: essential oils, fungi, antifungal activity, mechanism of action, mode of action
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Modulation of HIV-1 Protease Activity
Pokorná, Jana ; Konvalinka, Jan (advisor) ; Šedo, Aleksi (referee) ; Ruml, Tomáš (referee)
HIV-1 protease plays a crucial role in the late state of the life cycle of HIV virus when it cleaves the viral polyprotein precursors into the structural and functional proteins. If it is effectively inhibited, HIV particles remain immature and noninfectious. The application of highly active antiretroviral therapy (HAART) including protease inhibitors can reduce plasma HIV-1 levels below the detection limit in adherent patients and thus dramatically change their life expectancy. The clinical utility of the first inhibitors was limited by severe side effects, low bioavailability, high pill burdens, and rapid development of viral resistance under the selection pressure of HIV antiretrovirals. To overcome these difficulties, second-generation inhibitors were developed. Despite an indisputable improvement they brought to antiretroviral therapy, the development of new highly active HIV-1 protease inhibitors with optimal pharmacokinetic properties, higher metabolic stability, little off-target activity, and particularly, more favorable resistance profiles is still of high importance. This thesis provides an overview of anti-HIV- drugs including development of substituted metallacarboranes, a new class of potent, unusual, nonpeptidic HIV protease inhibitors with therapeutic potential. Next, the impact of...
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